Compensatory neural responses after 36 hours of total sleep deprivation and its relationship with executive control function

Yongcong Shao1, Jianlin Qi2, Ming Fan3, Enmao Ye3, Bo Wen4, Guohua Bi3, Zheng Yang3, Danmin Miao5
1Fourth Military Medical University, and Beijing Institute of Basic Medical Sciences, People’s Republic of China
2Fourth Military Medical University, and Air-force General Hospital, People’s Liberation Army of China, People’s Republic of China
3Beijing Institute of Basic Medical Sciences, People’s Republic of China
4General Hospital of the People’s Liberation Army of China, People’s Republic of China
5Fourth Military Medical University, People’s Republic of China
Cite this article:  Shao, Y., Qi, J., Fan, M., Ye, E., Wen, B., Bi, G., Yang, Z., & Miao, D. (2009). Compensatory neural responses after 36 hours of total sleep deprivation and its relationship with executive control function. Social Behavior and Personality: An international journal, 37, 1239-1250.

Volume 37 Issue 9 | e1940 | Published: October 2009 | DOI: https://doi.org/10.2224/sbp.2009.37.9.1239

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The neurobiological mechanisms of Total Sleep Deprivation (TSD) - induced changes in executive control function were investigated. Fourteen participants were measured by functional magnetic resonance imaging (fMRI) with the visual Go/No-go task after normal sleep and following 36 hours of TSD. The TSD-induced positive and negative blood oxygenation level-dependent (BOLD) signals compared with that after a normal night’s sleep (NORM). The areas activated with positive BOLD signals include the superior prefrontal cortex and inferior prefrontal cortex, with negative BOLD signals in the anterior cingulated cortex (ACC) and right lingual gyrus. Increased activation may be related to the compensatory response since more attention resources are needed to perform the Go/No-go task after 36 hours of TSD and the decreased activation in the ACC may reflect the impact of executive control function by the TSD.

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